The CDC notified clinicians, public health practitioners, and laboratorians of domestically acquired cases of cyclosporiasis in multiple US states. Since May 1, 2026, CDC has received reports of 1,645 confirmed domestic cases of cyclosporiasis and is aware of more than 5,100 cases that require further analysis to confirm domestically acquired cyclosporiasis. The numbers are substantially higher than the 249 cases reported nationwide at this time last year. Of the 1,645 case-patients with available information, 141 (9%) were hospitalized, and none have died. The CDC, the FDA, and state and local health departments are working together to investigate multistate outbreaks of Cyclospora infections and to identify the sources of illness. Because cyclosporiasis is often underdiagnosed and underreported, the true number of illnesses is likely higher than the number reported to the CDC. @ https://www.cdc.gov/han/php/notices/han00531.html#cdc_health_alert_section_1-summary