Scientist discover antibiotics with activity against multi-drug-resistant Gram-positive pathogens isolated from soil
Scientist from the Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, discovered a new antibiotic agent that they named malacidin. In rats, malacidin worked against methicillin-resistant Staphylococcus aureus. The researchers applied independent Natural products discovery platform that involves sequencing, bioinformatic analysis and heterologous expression of biosynthetic gene clusters captured on DNA extracted from environmental samples. Malacidins, a distinctive class of antibiotics that are commonly encoded in soil microbiomes but have never been reported in culture-based NP discovery efforts. @ https://www.nature.com/articles/s41564-018-0110-1
Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens
Analysis of secondary metabolite biosynthesis clusters from diverse soil samples identifies a distinct class of calcium-dependent antibiotics—the malacidins—that bind lipid II and are active against multidrug-resistant Gram-positive pathogens.