Scientist from the College of Veterinary Medicine, University of Florida, Gainesville, Florida, published in Microbiology Spectrum the article entitled “Commensal Escherichia coli inhibits the growth and modulates the fitness, virulence, and antimicrobial resistance of Salmonella Heidelberg in vitro”. Nontyphoidal Salmonella (NTS) are major foodborne pathogens primarily transmitted to humans through contaminated poultry products. Increased antimicrobial resistance (AMR) in NTS, including Salmonella Heidelberg (SH), has recently become a public health issue. Current control measures are inadequate, emphasizing the need for novel approaches to mitigate NTS colonization in poultry and contamination of poultry products. Several genes involved in bacterial growth, pathogenicity and virulence, biofilm formation, metal-ion homeostasis, signal transduction and chemotaxis, stress response, transmembrane transport of xenobiotics, and cellular metabolism were downregulated by as much as 86-folds in SH as compared to the control. The study revealed the downregulation of genes associated with AMR and drug efflux in SH by up to 12 folds. These findings highlight that commensal E. coli may reduce the fitness, persistence, virulence, and AMR dissemination of SH, implying that E. coli strains could be utilized to mitigate antibiotic-resistant SH in poultry, ultimately enhancing food safety. The study provides insights into the ability of commensal E. coli to reduce SH colonization of chicken intestines and the genes involved in that change. The study showed that commensal E. coli significantly reduced antibiotic-resistant SH counts and expression of Salmonella genes, which play a vital role in their growth and persistence. Suggesting the potential use of commensal E. coli to control antibiotic-resistant SH colonization in poultry, leading to improved food safety through reduced NTS contamination of foods of poultry origin and reduced dissemination of antibiotic-resistant Salmonella to humans via the food chain. @ https://journals.asm.org/doi/pdf/10.1128/spectrum.03336-24