Scientist from the Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, discovered a new antibiotic agent that they named malacidin. In rats, malacidin worked against methicillin-resistant Staphylococcus aureus. The researchers applied independent Natural products discovery platform that involves sequencing, bioinformatic analysis and heterologous expression of biosynthetic gene clusters captured on DNA extracted from environmental samples. Malacidins, a distinctive class of antibiotics that are commonly encoded in soil microbiomes but have never been reported in culture-based NP discovery efforts. @ https://www.nature.com/articles/s41564-018-0110-1
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Analysis of secondary metabolite biosynthesis clusters from diverse soil samples identifies a distinct class of calcium-dependent antibiotics—the malacidins—that bind lipid II and are active against multidrug-resistant Gram-positive pathogens.
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The FDA releases 2017 Food Code for Retail Food Protection
The FDA announced today the release of the 2017 edition of the FDA Food Code, a model regulation that provides all levels of government and industry with practical, science-based guidance and manageable provisions for reducing the known risks of foodborne illness. The code represents FDA’s recommendations for a uniform system of provisions that address the safety and protection of food offered at retail and in food service. It establishes a more standardized approach to controlling food safety hazards within a retail environment. One of the significant changes is the requirement for the Person in Charge (PIC) to be a Certified Food Protection Manager. @ https://www.fda.gov/Food/GuidanceRegulation/RetailFoodProtection/ucm2006807.htm
A listing of food protection references for operators of
retail food stores and food service establishments and other interested parties including
information on National Food Safety Education Month and the Food Code.
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The Trend to Outsource Pathogen Testing Continues
According to Bob Ferguson, pathogen testing is moving more and more to outside testing laboratories due to regulatory pressures and a stronger focus on food safety. While the total volume of microbiology testing is growing at 5-6%/y, the contract lab volume is increasing at 10-12%/y. One interesting observation of the survey was that seasoned lab directors had a higher tendency to keep the testing in-house. @ https://www.foodsafetymagazine.com/magazine-archive1/december-2017january-2018/outsourcing-pathogen-testing-under-the-microscope/?mobileFormat=false
The way processors view their responsibilities regarding microbiological testing is changing. Regulatory pressure and a focus on food safety are causing changes in where processors do their testing.