Drug resistant fungi are a growing problem worldwide. Cell Chemical Biology published (Iyer, K. R., et al. (2023) Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chemical Biology) a study by RIKEN Center for Sustainable Research Science (CSRS) and the University of Toronto have discovered a new way to attack fungal infections. The key is to block fungi from being able to make fatty acids, the major component of fats. Currently, there are only three major classes of antifungal medications, and all of them work by destroying the barrier that surrounds fungal cells. A compound named NPD6433 was the least toxic to human cells and reduced the growth of Aspergillus fumigates. The researchers looked at how much NPD6433 suppressed growth in yeast when the yeast was missing one copy of the gene. They found that reduction in only one gene, fatty acid synthase, made yeast more susceptible to NPD6433. This result meant that NPD6433 likely works by inhibiting fatty acid synthase and thus prevents fatty acids from being made inside fungal cells. Further experiments showed that NPD6433 and cerulenin, another fatty acid synthase inhibitor, were able to kill numerous yeast species in culture. Tests showed that treating infected worms with NPD6433 reduced fatalities by about 50%. Importantly, this was true in worms infected with yeast resistant to standard antifungal medication. @ https://www.news-medical.net/news/20230731/New-way-to-attack-fungal-infections-discovered.aspx
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Researchers at the RIKEN Center for Sustainable Research Science (CSRS) and the University of Toronto have discovered a new way to attack fungal infections.
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Romaine lettuce imported from the US has been associated with several outbreaks of foodborne E. coli O157:H7 illnesses in Canada. The source of the outbreaks was identified as California Salinas Valley counties of Santa Cruz, Santa Clara, San Benito, and Monterey. To decrease the risk associated with E. coli O157:H7 in romaine lettuce, the CFIA is implementing temporary Safe Food for Canadians (SFC) license requirements for the importation of romaine lettuce originating from the US Between September 28 and December 20, 2023. Importers must declare that the lettuce does not come from the counties identified or submit a COA demonstrating that the romaine lettuce does not contain detectable levels of E. coli O157:H7. @ https://inspection.canada.ca/importing-food-plants-or-animals/food-imports/food-specific-requirements/romaine-lettuce-from-the-united-states/eng/1601488215302/1601488215678
Romaine lettuce imported from the United States has been associated with several outbreaks of foodborne E. coli O157:H7 illnesses in Canada and the USA
ruth
Romaine lettuce imported from the US has been associated with several outbreaks of foodborne E. coli O157:H7 illnesses in Canada. The source of the outbreaks was identified as California Salinas Valley counties of Santa Cruz, Santa Clara, San Benito, and Monterey. To decrease the risk associated with E. coli O157:H7 in romaine lettuce, the CFIA is implementing temporary Safe Food for Canadians (SFC) license requirements for the importation of romaine lettuce originating from the US Between September 28 and December 20, 2023. Importers must declare that the lettuce does not come from the counties identified or submit a COA demonstrating that the romaine lettuce does not contain detectable levels of E. coli O157:H7. @ https://inspection.canada.ca/importing-food-plants-or-animals/food-imports/food-specific-requirements/romaine-lettuce-from-the-united-states/eng/1601488215302/1601488215678
Romaine lettuce imported from the United States has been associated with several outbreaks of foodborne E. coli O157:H7 illnesses in Canada and the USA
ruth
Romaine lettuce imported from the US has been associated with several outbreaks of foodborne E. coli O157:H7 illnesses in Canada. The source of the outbreaks was identified as California Salinas Valley counties of Santa Cruz, Santa Clara, San Benito, and Monterey. To decrease the risk associated with E. coli O157:H7 in romaine lettuce, the CFIA is implementing temporary Safe Food for Canadians (SFC) license requirements for the importation of romaine lettuce originating from the US Between September 28 and December 20, 2023. Importers must declare that the lettuce does not come from the counties identified or submit a COA demonstrating that the romaine lettuce does not contain detectable levels of E. coli O157:H7. @ https://inspection.canada.ca/importing-food-plants-or-animals/food-imports/food-specific-requirements/romaine-lettuce-from-the-united-states/eng/1601488215302/1601488215678
Romaine lettuce imported from the United States has been associated with several outbreaks of foodborne E. coli O157:H7 illnesses in Canada and the USA