The FSIS issued a report on its investigation of 2025 outbreaks involving its inspected products. The report includes outbreaks that involve four foodborne pathogens that most frequently contaminate FSIS-inspected products: Salmonella, Shiga toxin-producing Escherichia coli (STEC), Listeria monocytogenes, and Campylobacter. The USDA FSIS products include meat, poultry, or egg products linked to human illnesses. The report summarizes outbreaks that FSIS investigated in Fiscal Year 2025, from October 1, 2024, to September 30, 2025. The report also highlights key lessons learned from outbreak investigations in FY 2025. During FY 2025, FSIS investigated seven outbreaks in coordination with local, state, and federal public health partners. These outbreaks involved approximately 250 illnesses and 140 hospitalizations. The CDC notified FSIS of five outbreaks (71%). All seven (100%) outbreaks involved illnesses in more than one state. Of the seven outbreaks investigated by FSIS in FY 2025, one was caused by Salmonella (serotype Enteritidis), two by E. coli O157:H7, and four by Listeria monocytogenes (Figure 1). Beef was of interest in two outbreaks: ready-to-eat (RTE) meat and poultry products in one, and multi-ingredient foods in two. Multiple products were investigated in two outbreaks in FY 2025 (Figure 2). @